S15T (p.Ser15Thr) variant of IL6 (Interleukin-6)
S15T (p.Ser15Thr) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
S15T (p.Ser15Thr) variant details
- p.Ser15Thr
- gnomAD rs1291977570
- Missense
- Variant Prioritization Score for Impact Estimate 0.328
- REVEL 0.23
- MetaLR 0.46
- MetaSVM -0.57
- CADD 23.90
- PolyPhen-2 0.98
- SIFT 0.02
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available