S15F (p.Ser15Phe) variant of IL6 (Interleukin-6)
S15F (p.Ser15Phe) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data, published literature, and structural context.
S15F (p.Ser15Phe) variant details
- p.Ser15Phe
- gnomAD 7-22727468-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.385
- REVEL 0.37
- MetaLR 0.50
- MetaSVM -0.52
- CADD 24.20
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- Literature evidence available