S15C (p.Ser15Cys) variant of IL6 (Interleukin-6)
S15C (p.Ser15Cys) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
S15C (p.Ser15Cys) variant details
- p.Ser15Cys
- gnomAD rs1337461123
- Missense
- Variant Prioritization Score for Impact Estimate 0.363
- REVEL 0.34
- MetaLR 0.50
- MetaSVM -0.52
- CADD 22.90
- PolyPhen-2 1.00
- SIFT 0.06
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available