R58W (p.Arg58Trp) variant of IL6 (Interleukin-6)
R58W (p.Arg58Trp) in IL6 (Interleukin-6) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data and structural context.
R58W (p.Arg58Trp) variant details
- p.Arg58Trp
- NCI-TCGA Cosmic COSV5173
- cosmic curated COSV51732
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.133
- REVEL 0.08
- MetaLR 0.03
- MetaSVM -1.03
- CADD 15.10
- PolyPhen-2 0.01
- SIFT 0.07
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 2.5e-05)
- Structural context available