R44S (p.Arg44Ser) variant of IL6 (Interleukin-6)
R44S (p.Arg44Ser) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
R44S (p.Arg44Ser) variant details
- p.Arg44Ser
- gnomAD rs1397087240
- Missense
- Variant Prioritization Score for Impact Estimate 0.243
- REVEL 0.25
- MetaLR 0.25
- MetaSVM -0.88
- CADD 11.60
- PolyPhen-2 0.05
- SIFT 0.13
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available