Q56H (p.Gln56His) variant of IL6 (Interleukin-6)
Q56H (p.Gln56His) in IL6 (Interleukin-6) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
Q56H (p.Gln56His) variant details
- p.Gln56His
- rs199925567
- ClinGen CA4185323
- ClinVar RCV004283203
- ExAC rs199925567
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.162
- REVEL 0.05
- MetaLR 0.02
- MetaSVM -1.03
- CADD 3.08
- PolyPhen-2 0.00
- SIFT 0.28
- ClinVar: Likely benign (not specified)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the Non-Finnish European population (allele frequency 4.4e-05)
- Structural context available