P42A (p.Pro42Ala) variant of IL6 (Interleukin-6)
P42A (p.Pro42Ala) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
P42A (p.Pro42Ala) variant details
- p.Pro42Ala
- ExAC rs770802865
- TOPMed rs770802865
- gnomAD rs770802865
- Missense
- Variant Prioritization Score for Impact Estimate 0.15
- REVEL 0.11
- MetaLR 0.28
- MetaSVM -0.73
- CADD 6.46
- PolyPhen-2 0.28
- SIFT 0.77
- Most common in the Latino/Admixed American population (allele frequency 0.00023)
- Structural context available