P32S (p.Pro32Ser) variant of IL6 (Interleukin-6)
P32S (p.Pro32Ser) in IL6 (Interleukin-6) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as benign in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data, published literature, and structural context.
P32S (p.Pro32Ser) variant details
- p.Pro32Ser
- rs2069830
- ClinGen CA4185311
- ClinVar RCV000947003
- UniProt VAR 013075
- Benign
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.187
- REVEL 0.17
- MetaLR 0.01
- MetaSVM -1.05
- CADD 5.05
- PolyPhen-2 0.00
- SIFT 0.75
- ClinVar: Benign (not provided)
- EBI: Benign (in dbSNP:rs2069830)
- UniProt: Benign (in dbSNP:rs2069830)
- Most common in the HGDP:YORUBA population (allele frequency 0.14)
- Structural context available
- Literature evidence available