P31T (p.Pro31Thr) variant of IL6 (Interleukin-6)
P31T (p.Pro31Thr) in IL6 (Interleukin-6) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as benign in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
P31T (p.Pro31Thr) variant details
- p.Pro31Thr
- rs142759801
- ClinGen CA4185309
- ClinVar RCV000880472
- ClinVar RCV003930512
- Benign
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.14
- REVEL 0.08
- MetaLR 0.14
- MetaSVM -0.91
- CADD 3.65
- PolyPhen-2 0.00
- SIFT 0.45
- ClinVar: Benign (not provided)
- EBI: Benign
- UniProt: Benign
- Most common in the HGDP:MANDENKA population (allele frequency 0.075)
- Structural context available