P31S (p.Pro31Ser) variant of IL6 (Interleukin-6)
P31S (p.Pro31Ser) in IL6 (Interleukin-6) is a missense change. Clinical records from EBI and UniProt describe it as benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
P31S (p.Pro31Ser) variant details
- p.Pro31Ser
- 1000Genomes rs142759801
- ESP rs142759801
- ExAC rs142759801
- TOPMed rs142759801
- Benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.151
- REVEL 0.09
- MetaLR 0.24
- MetaSVM -0.91
- CADD 4.37
- PolyPhen-2 0.07
- SIFT 0.45
- EBI: Benign
- UniProt: Benign
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available