P31H (p.Pro31His) variant of IL6 (Interleukin-6)
P31H (p.Pro31His) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
P31H (p.Pro31His) variant details
- p.Pro31His
- ExAC rs778465778
- TOPMed rs778465778
- gnomAD rs778465778
- Missense
- Variant Prioritization Score for Impact Estimate 0.136
- REVEL 0.10
- MetaLR 0.42
- MetaSVM -0.60
- CADD 0.78
- PolyPhen-2 0.01
- SIFT 0.57
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available