P11R (p.Pro11Arg) variant of IL6 (Interleukin-6)
P11R (p.Pro11Arg) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data, published literature, and structural context.
P11R (p.Pro11Arg) variant details
- p.Pro11Arg
- gnomAD 7-22727456-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.4
- REVEL 0.37
- MetaLR 0.50
- MetaSVM -0.35
- CADD 23.40
- PolyPhen-2 0.85
- SIFT 0.00
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available
- Literature evidence available