L22F (p.Leu22Phe) variant of IL6 (Interleukin-6)
L22F (p.Leu22Phe) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
L22F (p.Leu22Phe) variant details
- p.Leu22Phe
- TOPMed rs1207045699
- gnomAD rs1207045699
- Missense
- Variant Prioritization Score for Impact Estimate 0.24
- REVEL 0.15
- MetaLR 0.21
- MetaSVM -0.84
- CADD 20.50
- PolyPhen-2 0.01
- SIFT 0.02
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available