I60T (p.Ile60Thr) variant of IL6 (Interleukin-6)
I60T (p.Ile60Thr) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
I60T (p.Ile60Thr) variant details
- p.Ile60Thr
- cosmic curated COSV51733
- TOPMed rs1002676051
- gnomAD rs1002676051
- Missense
- Variant Prioritization Score for Impact Estimate 0.368
- REVEL 0.33
- MetaLR 0.15
- MetaSVM -0.96
- CADD 23.30
- PolyPhen-2 0.99
- SIFT 0.07
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available