I57L (p.Ile57Leu) variant of IL6 (Interleukin-6)
I57L (p.Ile57Leu) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
I57L (p.Ile57Leu) variant details
- p.Ile57Leu
- TOPMed rs1187509514
- gnomAD rs1187509514
- Missense
- Variant Prioritization Score for Impact Estimate 0.177
- REVEL 0.14
- MetaLR 0.11
- MetaSVM -1.03
- CADD 16.30
- PolyPhen-2 0.88
- SIFT 0.09
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available