I53S (p.Ile53Ser) variant of IL6 (Interleukin-6)
I53S (p.Ile53Ser) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data, published literature, and structural context.
I53S (p.Ile53Ser) variant details
- p.Ile53Ser
- gnomAD 7-22727582-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.163
- REVEL 0.19
- CADD 8.75
- PolyPhen-2 0.02
- SIFT 0.17
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- Literature evidence available