H43R (p.His43Arg) variant of IL6 (Interleukin-6)
H43R (p.His43Arg) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data and structural context.
H43R (p.His43Arg) variant details
- p.His43Arg
- ExAC rs780174319
- Missense
- Variant Prioritization Score for Impact Estimate 0.122
- REVEL 0.06
- MetaLR 0.17
- MetaSVM -0.96
- CADD 12.00
- PolyPhen-2 0.00
- SIFT 0.05
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available