G63C (p.Gly63Cys) variant of IL6 (Interleukin-6)
G63C (p.Gly63Cys) in IL6 (Interleukin-6) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
G63C (p.Gly63Cys) variant details
- p.Gly63Cys
- rs752257060
- NCI-TCGA Cosmic COSV9933
- cosmic curated COSV99331
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.285
- REVEL 0.22
- AlphaMissense 0.12
- MetaLR 0.03
- MetaSVM -1.04
- CADD 21.00
- PolyPhen-2 0.93
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 2.6e-05)
- Structural context available