F4V (p.Phe4Val) variant of IL6 (Interleukin-6)
F4V (p.Phe4Val) in IL6 (Interleukin-6) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
F4V (p.Phe4Val) variant details
- p.Phe4Val
- rs958965295
- NCI-TCGA Cosmic COSV5173
- cosmic curated COSV51732
- gnomAD rs958965295
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.304
- REVEL 0.13
- MetaLR 0.15
- MetaSVM -0.98
- CADD 14.70
- PolyPhen-2 0.00
- SIFT 0.11
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 6.6e-05)
- Structural context available