F4S (p.Phe4Ser) variant of IL6 (Interleukin-6)
F4S (p.Phe4Ser) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data, published literature, and structural context.
F4S (p.Phe4Ser) variant details
- p.Phe4Ser
- gnomAD 7-22727273-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.261
- REVEL 0.18
- MetaLR 0.22
- MetaSVM -0.84
- CADD 23.20
- PolyPhen-2 0.02
- SIFT 0.01
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- Literature evidence available