F14C (p.Phe14Cys) variant of IL6 (Interleukin-6)
F14C (p.Phe14Cys) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
F14C (p.Phe14Cys) variant details
- p.Phe14Cys
- TOPMed rs986803797
- Missense
- Variant Prioritization Score for Impact Estimate 0.435
- REVEL 0.40
- MetaLR 0.58
- MetaSVM 0.19
- CADD 25.90
- PolyPhen-2 0.96
- SIFT 0.05
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available