D62N (p.Asp62Asn) variant of IL6 (Interleukin-6)
D62N (p.Asp62Asn) in IL6 (Interleukin-6) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
D62N (p.Asp62Asn) variant details
- p.Asp62Asn
- NCI-TCGA Cosmic COSV5173
- cosmic curated COSV51732
- TOPMed rs1784036209
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.0952
- REVEL 0.05
- MetaLR 0.03
- MetaSVM -0.92
- CADD 4.58
- PolyPhen-2 0.04
- SIFT 0.62
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 2.6e-05)
- Structural context available