D35V (p.Asp35Val) variant of IL6 (Interleukin-6)
D35V (p.Asp35Val) in IL6 (Interleukin-6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
D35V (p.Asp35Val) variant details
- p.Asp35Val
- ExAC rs201787553
- TOPMed rs201787553
- gnomAD rs201787553
- Missense
- Variant Prioritization Score for Impact Estimate 0.314
- REVEL 0.25
- MetaLR 0.49
- MetaSVM -0.58
- CADD 23.60
- PolyPhen-2 0.97
- SIFT 0.04
- Most common in the Middle Eastern population (allele frequency 0.00035)
- Structural context available