Y38C (p.Tyr38Cys) variant of IL4R (P24394)
Y38C (p.Tyr38Cys) in IL4R (P24394) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
Y38C (p.Tyr38Cys) variant details
- p.Tyr38Cys
- NCI-TCGA Cosmic COSV9940
- cosmic curated COSV99405
- TOPMed rs1775077711
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.27
- REVEL 0.19
- CADD 22.70
- PolyPhen-2 0.95
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available