P18S (p.Pro18Ser) variant of IL2RB (P14784)
P18S (p.Pro18Ser) in IL2RB (P14784) is a missense change. Clinical records from ClinVar and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data.
P18S (p.Pro18Ser) variant details
- p.Pro18Ser
- TOPMed rs1001259966
- gnomAD rs1001259966
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.21
- REVEL 0.32
- CADD 0.09
- PolyPhen-2 0.01
- SIFT 0.53
- ClinVar: Likely benign (not specified)
- UniProt: Likely benign
- Most common in the African/African-American population (allele frequency 2.4e-05)