W131* (p.Trp131Ter) variant of IL2RA (P01589)
W131* (p.Trp131Ter) in IL2RA (P01589) is a protein-truncating change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.86 / 1. The record also includes population frequency data and structural context.
W131* (p.Trp131Ter) variant details
- p.Trp131Ter
- NCI-TCGA Cosmic COSV5691
- cosmic curated COSV56919
- Variant assessed as somatic; high impact.
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.856
- CADD 37.00
- UniProt: Variant assessed as somatic; high impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available