E103K (p.Glu103Lys) variant of IL2RA (P01589)
E103K (p.Glu103Lys) in IL2RA (P01589) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
E103K (p.Glu103Lys) variant details
- p.Glu103Lys
- NCI-TCGA Cosmic COSV5692
- NCI-TCGA Cosmic COSV9990
- cosmic curated COSV99906
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.111
- REVEL 0.03
- CADD 8.09
- PolyPhen-2 0.01
- SIFT 0.18
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available