L14F (p.Leu14Phe) variant of IL23R (Interleukin-23 receptor)
L14F (p.Leu14Phe) in IL23R (Interleukin-23 receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
L14F (p.Leu14Phe) variant details
- p.Leu14Phe
- gnomAD rs1292287814
- Missense
- Variant Prioritization Score for Impact Estimate 0.265
- REVEL 0.31
- CADD 6.83
- PolyPhen-2 0.38
- SIFT 0.19
- Most common in the Latino/Admixed American population (allele frequency 0.00013)
- Structural context available