V21A (p.Val21Ala) variant of IL1RAPL1 (Q9NZN1)
V21A (p.Val21Ala) in IL1RAPL1 (Q9NZN1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
V21A (p.Val21Ala) variant details
- p.Val21Ala
- TOPMed rs1330799870
- gnomAD rs1330799870
- NCI-TCGA Cosmic COSV5627
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.334
- REVEL 0.20
- CADD 20.80
- PolyPhen-2 0.01
- SIFT 0.40
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available