S18G (p.Ser18Gly) variant of IL1RAPL1 (Q9NZN1)
S18G (p.Ser18Gly) in IL1RAPL1 (Q9NZN1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
S18G (p.Ser18Gly) variant details
- p.Ser18Gly
- NCI-TCGA Cosmic COSV5626
- NCI-TCGA Cosmic COSV9904
- TOPMed rs1936510256
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.295
- REVEL 0.19
- CADD 19.90
- PolyPhen-2 0.01
- SIFT 0.68
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available