R106W (p.Arg106Trp) variant of IL1RAPL1 (Q9NZN1)
R106W (p.Arg106Trp) in IL1RAPL1 (Q9NZN1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data and structural context.
R106W (p.Arg106Trp) variant details
- p.Arg106Trp
- rs766627012
- NCI-TCGA Cosmic COSV5626
- ExAC rs766627012
- TOPMed rs766627012
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.522
- REVEL 0.56
- CADD 23.60
- PolyPhen-2 0.98
- SIFT 0.16
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available