W57* (p.Trp57Ter) variant of IL1R1 (Interleukin-1 receptor type 1)

Name: IL1R1 W57* (p.Trp57Ter) variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-08-20
License: https://catvariant.com/terms-of-use

W57* (p.Trp57Ter) in IL1R1 (Interleukin-1 receptor type 1) is a protein-truncating change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.85 / 1. The record also includes population frequency data and structural context.

W57* (p.Trp57Ter) variant details

p.Trp57Ter
NCI-TCGA Cosmic COSV9929
cosmic curated COSV99292
Variant assessed as somatic; high impact.
Stop Gained
Variant Prioritization Score for Impact Estimate 0.848
CADD 36.00
UniProt: Variant assessed as somatic; high impact.
Most common in the Non-Finnish European population (allele frequency 9e-07)
Structural context available