V69L (p.Val69Leu) variant of IL1B (Interleukin-1 beta)
V69L (p.Val69Leu) in IL1B (Interleukin-1 beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
V69L (p.Val69Leu) variant details
- p.Val69Leu
- TOPMed rs1438718924
- gnomAD rs1438718924
- Missense
- Variant Prioritization Score for Impact Estimate 0.328
- REVEL 0.26
- MetaLR 0.25
- MetaSVM -0.70
- CADD 12.60
- PolyPhen-2 0.37
- SIFT 0.01
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available