V4I (p.Val4Ile) variant of IL1B (Interleukin-1 beta)
V4I (p.Val4Ile) in IL1B (Interleukin-1 beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data and structural context.
V4I (p.Val4Ile) variant details
- p.Val4Ile
- ExAC rs755035830
- TOPMed rs755035830
- gnomAD rs755035830
- Missense
- Variant Prioritization Score for Impact Estimate 0.546
- REVEL 0.39
- MetaLR 0.50
- MetaSVM 0.31
- CADD 24.70
- PolyPhen-2 0.97
- SIFT 0.01
- Most common in the South Asian population (allele frequency 0.00015)
- Structural context available