S53Y (p.Ser53Tyr) variant of IL1B (Interleukin-1 beta)
S53Y (p.Ser53Tyr) in IL1B (Interleukin-1 beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data and structural context.
S53Y (p.Ser53Tyr) variant details
- p.Ser53Tyr
- TOPMed rs1449638481
- Missense
- Variant Prioritization Score for Impact Estimate 0.501
- REVEL 0.36
- MetaLR 0.41
- MetaSVM -0.34
- CADD 23.70
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available