P43R (p.Pro43Arg) variant of IL1B (Interleukin-1 beta)
P43R (p.Pro43Arg) in IL1B (Interleukin-1 beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data, published literature, and structural context.
P43R (p.Pro43Arg) variant details
- p.Pro43Arg
- gnomAD 2-112833547-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.154
- REVEL 0.13
- MetaLR 0.07
- MetaSVM -1.04
- CADD 11.80
- PolyPhen-2 0.46
- SIFT 0.34
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- Literature evidence available