L90P (p.Leu90Pro) variant of IL1B (Interleukin-1 beta)
L90P (p.Leu90Pro) in IL1B (Interleukin-1 beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
L90P (p.Leu90Pro) variant details
- p.Leu90Pro
- TOPMed rs1459050542
- gnomAD rs1459050542
- Missense
- Variant Prioritization Score for Impact Estimate 0.299
- REVEL 0.28
- MetaLR 0.19
- MetaSVM -0.79
- CADD 18.70
- PolyPhen-2 0.27
- SIFT 0.05
- Most common in the Latino/Admixed American population (allele frequency 0.0023)
- Structural context available