L74P (p.Leu74Pro) variant of IL1B (Interleukin-1 beta)
L74P (p.Leu74Pro) in IL1B (Interleukin-1 beta) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
L74P (p.Leu74Pro) variant details
- p.Leu74Pro
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.462
- REVEL 0.47
- MetaLR 0.25
- MetaSVM -0.52
- CADD 23.60
- PolyPhen-2 0.51
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available