L50I (p.Leu50Ile) variant of IL1B (Interleukin-1 beta)
L50I (p.Leu50Ile) in IL1B (Interleukin-1 beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
L50I (p.Leu50Ile) variant details
- p.Leu50Ile
- TOPMed rs1191166603
- gnomAD rs1191166603
- Missense
- Variant Prioritization Score for Impact Estimate 0.399
- REVEL 0.37
- MetaLR 0.38
- MetaSVM -0.29
- CADD 22.60
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available