L39V (p.Leu39Val) variant of IL1B (Interleukin-1 beta)
L39V (p.Leu39Val) in IL1B (Interleukin-1 beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data, published literature, and structural context.
L39V (p.Leu39Val) variant details
- p.Leu39Val
- gnomAD 2-112833560-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.136
- REVEL 0.04
- MetaLR 0.08
- MetaSVM -1.03
- CADD 8.11
- PolyPhen-2 0.21
- SIFT 0.12
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- Literature evidence available