I52L (p.Ile52Leu) variant of IL1B (Interleukin-1 beta)
I52L (p.Ile52Leu) in IL1B (Interleukin-1 beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
I52L (p.Ile52Leu) variant details
- p.Ile52Leu
- gnomAD rs1173863937
- Missense
- Variant Prioritization Score for Impact Estimate 0.0895
- REVEL 0.07
- MetaLR 0.08
- MetaSVM -1.02
- CADD 0.17
- PolyPhen-2 0.01
- SIFT 0.06
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available