G28S (p.Gly28Ser) variant of IL1B (Interleukin-1 beta)
G28S (p.Gly28Ser) in IL1B (Interleukin-1 beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
G28S (p.Gly28Ser) variant details
- p.Gly28Ser
- TOPMed rs1336527442
- gnomAD rs1336527442
- Missense
- Variant Prioritization Score for Impact Estimate 0.217
- REVEL 0.14
- MetaLR 0.20
- MetaSVM -0.94
- CADD 19.70
- PolyPhen-2 0.97
- SIFT 0.06
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available