F85L (p.Phe85Leu) variant of IL1B (Interleukin-1 beta)
F85L (p.Phe85Leu) in IL1B (Interleukin-1 beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data, published literature, and structural context.
F85L (p.Phe85Leu) variant details
- p.Phe85Leu
- gnomAD 2-112833420-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.254
- REVEL 0.20
- MetaLR 0.12
- MetaSVM -0.91
- CADD 17.20
- PolyPhen-2 0.13
- SIFT 0.31
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available