F85C (p.Phe85Cys) variant of IL1B (Interleukin-1 beta)
F85C (p.Phe85Cys) in IL1B (Interleukin-1 beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
F85C (p.Phe85Cys) variant details
- p.Phe85Cys
- ESP rs376341819
- ExAC rs376341819
- TOPMed rs376341819
- gnomAD rs376341819
- Missense
- Variant Prioritization Score for Impact Estimate 0.428
- REVEL 0.29
- MetaLR 0.34
- MetaSVM -0.31
- CADD 23.70
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available