E25K (p.Glu25Lys) variant of IL1B (Interleukin-1 beta)
E25K (p.Glu25Lys) in IL1B (Interleukin-1 beta) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
E25K (p.Glu25Lys) variant details
- p.Glu25Lys
- NCI-TCGA Cosmic COSV9964
- Variant assessed as somatic; high impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.461
- REVEL 0.34
- MetaLR 0.34
- MetaSVM -0.49
- CADD 26.00
- PolyPhen-2 0.92
- SIFT 0.00
- UniProt: Variant assessed as somatic; high impact.
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available