D89Y (p.Asp89Tyr) variant of IL1B (Interleukin-1 beta)
D89Y (p.Asp89Tyr) in IL1B (Interleukin-1 beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data, published literature, and structural context.
D89Y (p.Asp89Tyr) variant details
- p.Asp89Tyr
- gnomAD 2-112833410-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.422
- REVEL 0.35
- MetaLR 0.45
- MetaSVM 0.20
- CADD 22.50
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the South Asian population (allele frequency 3.5e-05)
- Structural context available
- Literature evidence available