D45N (p.Asp45Asn) variant of IL1B (Interleukin-1 beta)
D45N (p.Asp45Asn) in IL1B (Interleukin-1 beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data, published literature, and structural context.
D45N (p.Asp45Asn) variant details
- p.Asp45Asn
- gnomAD 2-112833542-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.247
- REVEL 0.17
- MetaLR 0.15
- MetaSVM -0.97
- CADD 15.40
- PolyPhen-2 0.06
- SIFT 0.07
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available