C42Y (p.Cys42Tyr) variant of IL1B (Interleukin-1 beta)
C42Y (p.Cys42Tyr) in IL1B (Interleukin-1 beta) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
C42Y (p.Cys42Tyr) variant details
- p.Cys42Tyr
- Ensembl rs1682030902
- Missense
- Variant Prioritization Score for Impact Estimate 0.376
- REVEL 0.13
- MetaLR 0.20
- MetaSVM -0.89
- CADD 22.20
- PolyPhen-2 0.91
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available