A65T (p.Ala65Thr) variant of IL1B (Interleukin-1 beta)
A65T (p.Ala65Thr) in IL1B (Interleukin-1 beta) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
A65T (p.Ala65Thr) variant details
- p.Ala65Thr
- rs755957216
- NCI-TCGA Cosmic COSV5452
- ExAC rs755957216
- TOPMed rs755957216
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.239
- REVEL 0.12
- MetaLR 0.07
- MetaSVM -1.02
- CADD 15.20
- PolyPhen-2 0.08
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the HGDP:UYGUR population (allele frequency 0.083)
- Structural context available