P35A (p.Pro35Ala) variant of IL18R1 (Interleukin-18 receptor 1)
P35A (p.Pro35Ala) in IL18R1 (Interleukin-18 receptor 1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data, published literature, and structural context.
P35A (p.Pro35Ala) variant details
- p.Pro35Ala
- gnomAD 2-102367869-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.249
- REVEL 0.18
- MetaLR 0.17
- MetaSVM -0.97
- CADD 17.40
- PolyPhen-2 0.61
- SIFT 0.45
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- Literature evidence available